Quiz on Leprosy Chemotherapy

Solve this quiz to test your knowledge on the chemotherapy of leprosy. If you score more than 80%, then you have got very good knowledge about it.

More than options can be correct.

1. Which organism causes leprosy?
   1. Mycobacterium tuberculosis
   2. Mycobacterium gravis
   3. Mycobacterium leprae
   4. E. coli
2. What is the other name of leprosy?
   1. Buffalo disease
   2. Hansen's disease
   3. Harry's disease
   4. None of the above
3. Which part of body does it affects?
   1. Peripheral nerves and mucosa of upper respiratory tract
   2. Stomach
   3. Heart
   4. Kidney
4. Which drugs are commonly used?
   1. Dapsone (4-4' diaminodiphenyl sulfone, DDS)
   2. Streptomycin
   3. Rifampicin
   4. Sulfones
5. What is the mode of action of sulfones?
   1. Inhibit de novo synthesis of folic acid of M. leprae
   2. Act on bacterial cell wall
   3. Inhibit protein synthesis
   4. Inhibit the synthesis of mitochondria
6. What is the antagonist of DDS?
   1. Benzene
   2. Meta-amino-benzoic acid
   3. Para-amino-benzoic acid
   4. Ortho-amino-benzoic acid
7. What are the adverse reactions of sulfones?
   1. Anorexia, vomiting and nausea
   2. Sensitization of skin, dermatitis, drug fever
   3. Hemolytic anemia, liver damage, hematuria
   4. Goitrogenesis
8. What is the dosage of rifampicin?
9. 1000 mg per day
10. 600mg per month
11. 1000 mg per month
12. 600 mg per day
13. What is the dosage for DDS?
    1. 100mg per day orally
    2. 0.2 ml of 20% DDS intramuscularly per week, with gradual increase to 0.8 ml weekly.
    3. 0.5 ml of 20% DDS intramuscularly per week, with gradual increase to 0.8 ml weekly.
    4. 100mg per week
14. Which of the following shows bacteriostatic effect?
    1. Streptomycin
    2. Rifampicin
    3. Dapsone
    4. Sulfone

Answers:

1. C
2. B
3. A
4. A,C,D
5. A
6. C
7. A,B,C,D
8. B,C
9. A,B
10. C, D