Quiz on Pairwise Sequence Alignment

A score of around 80% will ensure a good knowledge about Pairwise Sequence Alignment topic.

More than one option can be correct in the quiz.

1. How many ways two sequences can be aligned and compared?
   1. 1
   2. 2
   3. 3
   4. 4
2. Which algorithm local alignment use?
   1. Needleman and Wunsch
   2. Smith-Waterman
   3. Both
   4. None
3. Which algorithm global alignment use?
   1. Needleman and Wunsch
   2. Smith-Waterman
   3. Both
   4. None
4. Which of the following is the most commonly used scoring matrices?
   1. PAM
   2. BLOSUM
   3. Both
   4. None
5. What is the full form of PAM?
   1. Percent Accepted Mutation
   2. Point Accepted Mutation
   3. Both
   4. None
6. Who developed PAM matrices and in which year?
   1. Needleman and Wunsch, 1976
   2. Smith-Waterman, 1978
   3. Dayhoff et al., 1978
   4. Henikoff & Henikoff, 1992
7. What is the full form of BLOSUM?
   1. Block Substitution Mutation
   2. Basic Substitution Mutation
   3. Block Substitution Matrix
   4. Basic Substitution Matrix
8. Who developed BLOSUM matrices and in which year?
   1. Needleman and Wunsch, 1976
   2. Smith-Waterman, 1978
   3. Dayhoff et al., 1978
   4. Henikoff & Henikoff, 1992
9. In PAM matrix, scores are derived from which model?
   1. a) Needleman and Wunsch, 1976
   2. Smith-Waterman, 1978
   3. Dayhoff et al., 1978
   4. Markov model

ANSWERS:

1. B
2. B
3. A
4. A, B
5. A
6. C
7. C
8. D
9. D