Quiz on Tuberculosis Chemotherapy

Score of around 80% should ensure that you have good knowledge about this topic. Remember that multiple options can be correct.

1. Tuberculosis is caused by which organism?
   1. Mycobacterium tuberculosis
   2. Mycobacterium bovis
   3. E. coli
   4. S. aureus
2. How tuberculosis gets spread?
   1. Sneezing
   2. Coughing
   3. Talking
   4. Walking
3. Which part of body does it most commonly infects?
   1. Brain
   2. Pulmonary
   3. Stomach
   4. Legs
4. Why are they difficult to treat?
   1. They grow very slowly, only once in 1-2 days
   2. They become dormant and are called persisters
   3. Drug reach the target with difficulty
   4. Can multiply in macrophages
   5. Develop resistance
   6. Cell mediated immunity is slow
5. What type of drugs is used?
   1. Bactericidal
   2. Bacteriostatic
   3. Both a and b
6. Which of the following is the drug for tuberculosis?
   1. Rifampicin (R, R-cin, Rimactane)
   2. Streptomycin (S)
   3. Pyrazinamide (Z, Pyzina, Unipyranamide)
   4. Ethambutol (E, Themibutol, Combutol)
7. What is the source of rifampicin?
   1. Streptomyces mediteranei
   2. E. coli
   3. S. aureus
   4. B. subtilis
8. What is the mode of action of rifampicin?
   1. Inhibiting DNA-dependent RNA polymerase which stop gene expression
   2. Act on bacterial cell wall
   3. Inhibit protein synthesis
   4. None of the above
9. What are the common adverse reactions of rifampicin?
   1. Induce hepatic microsomal enzyme activity which increase drug metabolism rate
   2. Cause allergic reactions like skin rashes, diarrhea, hepatitis, jaundice, leucopenia, thrombocytopenia
   3. Optical neuritis
   4. Heart attack
10. What is the source of streptomycin?
    1. E. coli
    2. S. aureus
    3. Streptomyces griseus
    4. S. coli
11. What is the mode of action of streptomycin?
    1. Inhibit gene expression
    2. Bind to 30S ribosome and interfere with protein synthesis
    3. Rupture mitochondria
    4. None of the above
12. What are the common adverse reactions of streptomycin?
    1. Damage the 8th nerve
    2. Nausea, giddiness, allergic reactions, local irritation, depression
    3. Neuromuscular blockade
    4. Tubular necrosis in kidney and superinfection by Staphylococcus aureus and Candida
13. What is the mode of action of pyrazinaimde?
    1. It acts like a prodrug which gets converted into pyrazinoic acid which inhibits bacterial synthesis of mycolic acid
    2. It inhibits the electron transport chain
    3. It inhibits amylase activity
    4. It inhibits gene expression
14. What are the common adverse reactions of pyrazinamide?
    1. Skin rashes, nausea, anorexia, malaise, exanthema, arthralgia
    2. Toxic hepatitis and hepatic necrosis
    3. Jaundice
    4. Heart attack
15. What is the mode of action of ethambutol?
    1. It inhibits the synthesis of bacterial cell wall arabinosyl transferase
    2. It inhibits the synthesis of mycolic acid
    3. It prevents the cross linkage of peptidoglycans
    4. All of the above
16. What are the common adverse reactions of ethambutol?
    1. Affects eyes and can cause retrobulbar optic neuritis, poor color discrimination, decrease visual acuity, contraction of visual field
    2. Nausea, confusion, anorexia, headache
    3. Allergic reactions
    4. Skin rashes
17. Which of the following drug can act upon persisters?
    1. Streptomycin
    2. Ethambutol
    3. Pyrizinamide
    4. Rifampicin
18. Which form of ethambutol is active?
    1. Dextrorotatory
    2. Laevorotatory
19. Which of the following drug is bacteriostatic?
    1. Pyrazinamide
    2. Ethambutol
    3. Rifampicin
    4. Streptomycin
20. Which of the following drug is bactericidal?
    1. Pyrazinamide
    2. Ethambutol
    3. Rifampicin
    4. Streptomycin

Answers:

1. A,B
2. A,B,C
3. B
4. A,B,C,D,E,F
5. C
6. A,B,C,D
7. A
8. A
9. A,B,C
10. C
11. B
12. A,B,C,D
13. A
14. A,B,C
15. A
16. A,B,C
17. D
18. A
19. B
20. A,C,D